Gray matter correlations of cognition in incident Parkinson's disease
Identifieur interne : 000697 ( Main/Exploration ); précédent : 000696; suivant : 000698Gray matter correlations of cognition in incident Parkinson's disease
Auteurs : Turi O. Dalaker [États-Unis, Norvège] ; Robert Zivadinov [États-Unis] ; Jan P. Larsen [Norvège] ; Mona K. Beyer [Norvège] ; Jennifer L. Cox [États-Unis] ; Guido Alves [Norvège] ; Kolbjorn Bronnick [Norvège] ; Ole-Bjorn Tysnes [Norvège] ; Ronald Antulov [États-Unis, Croatie] ; Michael G. Dwyer [États-Unis] ; Dag Aarsland [Norvège]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
English descriptors
Abstract
We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22867
Affiliations:
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Cox</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Bronnick, Kolbjorn" sort="Bronnick, Kolbjorn" uniqKey="Bronnick K" first="Kolbjorn" last="Bronnick">Kolbjorn Bronnick</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Antulov, Ronald" sort="Antulov, Ronald" uniqKey="Antulov R" first="Ronald" last="Antulov">Ronald Antulov</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka</wicri:regionArea><wicri:noRegion>Rijeka</wicri:noRegion></affiliation></author><author><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="629">629</biblScope><biblScope unit="page" to="633">633</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DBF6FF96650F3C24E5371EC1814622AEE9053EE7</idno><idno type="DOI">10.1002/mds.22867</idno><idno type="ArticleID">MDS22867</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>brain atrophy</term><term>mild cognitive impairment</term><term>mri</term><term>voxel‐based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Croatie</li><li>Norvège</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. 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